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Long-term lymphocytic leukemia (CLL) is often a lymphoid malignancy characterized because of the proliferation and accumulation of mature CD5+ B cells during the blood, bone marrow and lymphoid tissues. The analysis of CLL involves the existence of ≥5 x109/L mono - clonal B cells of usual phenotype within the blood.

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Some diploma of immunophenotype overlap between CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. In case the prognosis is unsure determined by peripheral blood circulation cytometry, lymph node biopsy must be pursued.

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